Multi-step synthesis by using modular flow reactors: The preparation of Yne—ones and their use in heterocycle synthesis

Baxendale I R, Schou S C, Sedelmeier J, Ley S V

Chem Eur J 2010; 16: 89 – 94
http://dx.doi.org/10.1002/chem.200902906

Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne—ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).